1-832-206-4069
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catalog number: |
78935 |
| other_names: | mapkkk3, mekk3 |
amount: |
100μg |
| calculated_mw: | 71kda |
| host_species: | rabbit |
price: |
$318 |
swiss-prot no: |
q99759 |
form of antibody: |
|
storage/stability: |
|
immunogen: |
a synthesized peptide derived from human mekk3 |
purification: |
affinity purification |
specificity/sensitivity: |
|
applications: |
wb |
background: |
this gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse mekk3. its catalytic domain is closely related to those of several other kinases, including mouse mekk2, tobacco npk, and yeast ste11. northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. this protein directly regulates the stress-activated protein kinase (sapk) and extracellular signal-regulated protein kinase (erk) pathways by activating sek and mek1/2 respectively; it does not regulate the p38 pathway. in cotransfection assays, it enhanced transcription from a nuclear factor kappa-b (nfkb)-dependent reporter gene, consistent with a role in the sapk pathway. alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by refseq, jul 2008] |
references: |
|
appl_detail: |
wb 1:500 - 1:2000 |
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