product datasheet
mekk3 rabbit mab
catalog number: 78935
technical:tech@swbio.com
information:info@swbio.com
description
- storage:
- store at -20℃. avoid freeze / thaw cycles.|buffer: pbs with 0.02% sodium azide,0.05% bsa,50% glycerol,ph7.3.
- immunogen:
- a synthesized peptide derived from human mekk3
- appl_detail:
- wb 1:500 - 1:2000
- other_names:
- mapkkk3, mekk3
- purification:
- affinity purification
- background:
- this gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse mekk3. its catalytic domain is closely related to those of several other kinases, including mouse mekk2, tobacco npk, and yeast ste11. northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. this protein directly regulates the stress-activated protein kinase (sapk) and extracellular signal-regulated protein kinase (erk) pathways by activating sek and mek1/2 respectively; it does not regulate the p38 pathway. in cotransfection assays, it enhanced transcription from a nuclear factor kappa-b (nfkb)-dependent reporter gene, consistent with a role in the sapk pathway. alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by refseq, jul 2008]
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