ACVR1 Rabbit mAb

Catalog Number:

78853

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q04771

Form of Antibody:

Storage/Stability:

Immunogen:

Recombinant protein of human ACVR1.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF