product datasheet
acvr1 rabbit mab
catalog number: 78853
technical:tech@swbio.com
information:info@swbio.com
description
- storage:
- store at -20℃. avoid freeze / thaw cycles.|buffer: pbs with 0.02% sodium azide,50% glycerol,ph7.3.
- immunogen:
- recombinant protein of human acvr1.
- reactivity:
- human,mouse,rat
- appl_detail:
- wb 1:500 - 1:2000
- other_names:
- acvr1; actri; acvr1a; acvrlk2; alk2; fop; skr1; tsri; activin receptor type-1
- purification:
- affinity purification
- background:
- activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (tgf-beta) superfamily of structurally related signaling proteins. activins signal through a heteromeric complex of receptor serine kinases which include at least two type i ( i and ib) and two type ii (ii and iib) receptors. these receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. type i receptors are essential for signaling; and type ii receptors are required for binding ligands and for expression of type i receptors. type i and ii receptors form a stable complex after ligand binding, resulting in phosphorylation of type i receptors by type ii receptors. this gene encodes activin a type i receptor which signals a particular transcriptional response in concert with activin type ii receptors. mutations in this gene are associated with fibrodysplasia ossificans progressive.
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