Product Datasheet  
PLOD2 Polyclonal Antibody  
Catalog Number: 28422  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:O00469
    NCBI Gene ID:5352
  • Form of Antibody：  
  • Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fusion protein of human PLOD2 (NP_891988.1).
  • reactivity：  
  • Human
  • appl_detail：  
  • IF 1:50 - 1:100
  • other_names：  
  • PLOD2; BRKS2; LH2; TLH; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  • Purification：  
  • Affinity purification
  • Specificity：  
  • Applications：  
  • IF
  • Background：  
  • The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.



 
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