Product Datasheet  
NEDD4 Polyclonal Antibody  
Catalog Number: 27232  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P46934
    NCBI Gene ID:4734
  • Form of Antibody：  
  • Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.12.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fusion protein of human NEDD4 (NP_940682.2).
  • reactivity：  
  • Human
  • appl_detail：  
  • WB 1:500 - 1:2000
    IHC 1:50 - 1:200
  • other_names：  
  • NEDD4; NEDD4-1; RPF1; E3 ubiquitin-protein ligase NEDD4
  • Purification：  
  • Affinity purification
  • Specificity：  
  • Applications：  
  • WB,IHC
  • Background：  
  • This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN.



 
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