product datasheet
kifap3 rabbit mab
catalog number: 77548
catalog number: 77548
technical:tech@swbio.com
information:info@swbio.com
description
- storage:
- store at -20℃. avoid freeze / thaw cycles.|buffer: pbs with 0.02% sodium azide,0.05% bsa,50% glycerol,ph7.3.
- immunogen:
- a synthesized peptide derived from human kifap3
- reactivity:
- human,mouse,rat
- appl_detail:
- wb 1:500 - 1:2000
if 1:50 - 1:200
- other_names:
- fla3, kap-1, kap-3, kap3, smap, smg-gds, dj190i16.1
- purification:
- affinity purification
- background:
- the small g protein gdp dissociation stimulator (smg gds) is a regulator protein having two activities on a group of small g proteins including the rho and rap1 family members and ki-ras; one is to stimulate their gdp/gtp exchange reactions, and the other is to inhibit their interactions with membranes. the protein encoded by this gene contains 9 'armadillo' repeats and interacts with the smg gds protein through these repeats. this protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg gds. it is thought that this protein serves as a linker between human chromosome-associated polypeptide (hcap) and kif3a/b, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an atpase motor protein. several transcript variants encoding different isoforms have been found for this gene. [provided by refseq, mar 2011]
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