product datasheet
rpa70 rabbit mab
catalog number: 77410
technical:tech@swbio.com
information:info@swbio.com
description
- storage:
- store at -20℃. avoid freeze / thaw cycles.|buffer: pbs with 0.02% sodium azide,0.05% bsa,50% glycerol,ph7.3.
- immunogen:
- a synthesized peptide derived from human rpa70
- reactivity:
- human,mouse,rat
- appl_detail:
- wb 1:500 - 1:2000
ihc 1:50 - 1:200
if 1:50 - 1:200
- other_names:
- bco3, lca2, rp20, mrpe65, rd12, srpe65
- purification:
- affinity purification
- background:
- this gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. there are two forms of this protein, a soluble form called srpe65, and a palmitoylated, membrane-bound form known as mrpe65. mrpe65 serves as the palmitoyl donor for lecithin retinol acyl transferase (lrat), the enzyme that catalyzes the vitamin a to all trans retinol step of the chromophore regeneration process. both mrpe65 and srpe65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. mutations in this gene have been associated with leber congenital amaurosis type 2 (lca2) and retinitis pigmentosa. [provided by refseq, jul 2008]
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