Product Datasheet  
Pirh2 Antibody  
Catalog Number: 48445  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q96PM5
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu, Rt
  • appl_detail：  
  • WB: 1:500-1:1000
    IHC: 1:50-1:200
    ICC: 1:50-1:200

    FC: 1:100-1:200
  • other_names：  
  • Androgen receptor N terminal interacting protein antibody
    Androgen receptor N-terminal-interacting protein antibody
    ARNIP antibody
    CH-rich-interacting match with PLAG1 antibody
    CHIMP antibody
    E3 ubiquitin-protein ligase Pirh2 antibody
    hARNIP antibody
    hPirh2 antibody
    p53 induced protein with a RING H2 domain antibody
    p53-induced RING-H2 protein antibody
    PIRH2E antibody
    PIRH2F antibody
    PRO1996 antibody
    RCHY1 antibody
    Ring finger and CHY zinc finger domain containing 1 E3 ubiquitin protein ligase antibody
    RING finger and CHY zinc finger domain-containing protein 1 antibody
    RING finger protein 199 antibody
    RNF199 antibody
    ZCHY antibody
    ZFP 363 antibody
    zinc finger CHY type antibody
    Zinc finger protein 363 antibody
    ZN363_HUMAN antibody
    ZNF363 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC
  • Background：  
  • Pirh2, also known as Androgen receptor N-terminal-interacting protein (ARNIP), ZN363 or CHIMP, has p53-induced ubiquitin-protein ligase activity, promoting p53 degradation. The protein physically interacts with p53 and the resulting degradation of p53 renders Pirh2 an oncogenic protein as the loss of p53 function contributes to malignant tumor development. The gene encoding for the protein maps to chromosome 4q21.1 and transcription of this gene is regulated by p53. Pirh2 expression decreases the level of p53 and a decrease of endogenous Pirh2 expression ups p53 levels. Pirh2 is therefore considered, together with MDM2, to be acting as a negative regulator of p53 function.



 
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