Product Datasheet  
WHSC2 Antibody  
Catalog Number: 48444  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q9H3P2
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu, Rt
  • appl_detail：  
  • WB: 1:500-1:2,000
    IHC: 1:100-1:200
    ICC: 1:50-1:200

    FC: 1:100-1:200
  • other_names：  
  • FLJ10442 antibody
    FLJ25112 antibody
    Negative elongation factor A antibody
    Negative elongation factor polypeptide A antibody
    NELF A antibody
    NELF-A antibody
    NELFA antibody
    NELFA_HUMAN antibody
    P/OKcl.15 antibody
    P/OKcl15 antibody
    WHSC 2 antibody
    Whsc2 antibody
    Wolf Hirschhorn syndrome candidate 2 antibody
    Wolf Hirschhorn syndrome candidate 2 protein antibody
    Wolf-Hirschhorn syndrome candidate 2 protein antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC
  • Background：  
  • NELF-A, for negative elongation factor A, is a protein factor required for DRB-sensitive transcription. NELF-A is one of the five components of the multisubunit NELF complex that cooperates with DSIF to repress RNA polymerase II elongation. Control of transcription elongation requires a complex interplay between positive transcription elongation factor b (P-TEFb) and negative transcription elongation factors, DSIF and NELF. DSIF and NELF act as negative transcription elongation factors by increasing the time the polymerase spends at pause sites. DSIF/NELF inhibition of transcription is prevented by P-TEFb in cooperation with FACT. NELF-A is also known as WHSC2 (Wolf-Hirschhorn syndrome candidate 2). Wolf-Hirschhorn syndrome is a multiple malformation syndrome characterized by mental and developmental defects resulting from a hemizygous deletion of the distal short arm of chromosome 4 (4p16.3). The human NELF-A gene maps to chromosome 4p16.3 and encodes a 528 amino acid protein that is expressed in endothelial cells.



 
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