Product Datasheet  
RF1 Antibody  
Catalog Number: 48424  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P62495
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:2,000



    FC: 1:100-1:200
  • other_names：  
  • Cl1 protein antibody
    D5S1995 antibody
    ERF antibody
    eRF1 antibody
    ERF1_HUMAN antibody
    ETF1 antibody
    Eukaryotic peptide chain release factor subunit 1 antibody
    Eukaryotic release factor 1 antibody
    Eukaryotic translation termination factor 1 antibody
    MGC111066 antibody
    Polypeptide chain release factor 1 antibody
    Protein Cl1 antibody
    RF1 antibody
    Sup45 (yeast omnipotent suppressor 45) homolog like 1 antibody
    SUP45L1 antibody
    TB3 1 antibody
    TB3-1 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, FC
  • Background：  
  • Translation is carried out by the ribosome and several associated protein factors through three consecutive steps: initiation, elongation and termination. Termination of protein synthesis takes place when the ribosomal A site is occupied simultaneously by one of three stop codons and by a class 1 translation termination factor. In eukaryotes, this termination factor is the eukaryotic release factor 1 (eRF1), a protein that promotes hydrolysis of the last peptidyl-tRNA on the ribosome. eRF1 activity is stimulated by the association with the GTP-binding protein eRF3. eRF1 forms a quaternary complex with eRF3, GTP and the ribosome. This complex performs a dual role, where, in the "GTP state," it controls the positioning of eRF1 toward the stop codon and peptidyl-tRNA, and, in the "GDP state," it promotes the release of the eRFs from the ribosome. eRF1 contains a highly conserved Asn-Ile-Lys-Ser (NIKS) tetrapeptide, which is essential for the interaction of eRF1 with the ribosome. The gene encoding human eRF1 maps to chromosome 5q31.2.



 
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