Product Datasheet  
PLCG1 Antibody  
Catalog Number: 48404  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P19174
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu, Rt, Monkey
  • appl_detail：  
  • WB: 1:500-1:2,000
    IHC: 1:50-1:200
    ICC: 1:50-1:200

    FC: 1:100-1:200
  • other_names：  
  • 1 phosphatidyl D myo inositol 4 5 bisphosphate antibody
    1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1 antibody
    1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 antibody
    Inositoltrisphosphohydrolase antibody
    Monophosphatidylinositol phosphodiesterase antibody
    NCKAP3 antibody
    Phosphatidylinositol phospholipase C antibody
    Phosphoinositidase C antibody
    Phosphoinositide phospholipase C antibody
    Phosphoinositide phospholipase C-gamma-1 antibody
    Phospholipase C 148 antibody
    Phospholipase C gamma 1 antibody
    Phospholipase C-gamma-1 antibody
    Phospholipase C-II antibody
    PLC gamma 1 antibody
    PLC II antibody
    PLC-148 antibody
    PLC-gamma-1 antibody
    PLC-II antibody
    PLC1 antibody
    PLC148 antibody
    Plcg1 antibody
    PLCG1_HUMAN antibody
    PLCgamma1 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC
  • Background：  
  • Phospholipase C-gamma 1 (PLC g1) is an isozyme of the phosphoinositide-specific PLC family, which occupies a central role in hormonal signal transduction pathways and is a substrate for the epidermal growth factor receptor tyrosine kinase. Following activation of TrkB, PLC g1 is phosphorylated on Tyrosine 783, Tyrosine 771 and Tyrosine 1253. Tyrosine 783 lies just downstream of the kinase domain in a relatively short sequence motif characteristic of the Trk family of protein-tyrosine kinase receptors. The sequence around Tyrosine 783 fits a consensus sequence for binding PLC g1. PLC g1 also forms a complex with TrkB consistent with the possibility that one of the TrkB autophosphorylation sites provides a binding site for the PLC g1 SH2 domains, as is the case for other receptor protein-tyrosine kinases.



 
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