Product Datasheet  
PRDM1 Antibody  
Catalog Number: 48403  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:O75626
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:2,000

    ICC: 1:200-1:1,000

    FC: 1:100-1:200
  • other_names：  
  • B Lymphocyte Induced Maturation Protein 1 antibody
    Beta interferon gene positive regulatory domain I binding factor antibody
    Beta-interferon gene positive regulatory domain I-binding factor antibody
    BLIMP-1 antibody
    BLIMP1 antibody
    Positive Regulatory Domain I Binding Factor 1 antibody
    Positive regulatory domain I-binding factor 1 antibody
    PR Domain Containing 1 antibody
    PR domain containing 1 with ZNF domain antibody
    PR domain containing 1 with ZNF domain isoform 2 antibody
    PR domain containing protein 1 antibody
    PR domain zinc finger protein 1 antibody
    PR domain-containing protein 1 antibody
    PRDI BF1 antibody
    PRDI binding factor 1 antibody
    PRDI-BF1 antibody
    PRDI-binding factor 1 antibody
    PRDM 1 antibody
    Prdm1 antibody
    PRDM1_HUMAN antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, FC
  • Background：  
  • The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-BF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated.



 
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