Product Datasheet  
MuRF1 Antibody  
Catalog Number: 48394  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q969Q1
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  

  • IHC: 1:50-1:200
    ICC: 1:50-1:200

    FC: 1:50-1:100
  • other_names：  
  • E3 ubiquitin-protein ligase TRIM63 antibody
    FLJ32380 antibody
    IRF antibody
    Iris RING finger protein antibody
    MURF 1 antibody
    MURF-1 antibody
    MuRF1 antibody
    MURF2 antibody
    Muscle specific ring finger protein 1 antibody
    Muscle specific ring finger protein 2 antibody
    Muscle-specific RING finger protein 1 antibody
    OTTHUMP00000008701 antibody
    RING finger protein 28 antibody
    RNF 28 antibody
    RNF28 antibody
    SMRZ antibody
    Striated muscle RING zinc finger protein antibody
    TRI63_HUMAN antibody
    TRIM 63 antibody
    Trim63 antibody
    Tripartite motif containing 63 antibody
    tripartite motif containing 63, E3 ubiquitin protein ligase antibody
    Tripartite motif containing protein 63 antibody
    Tripartite motif-containing protein 63 antibody
    Ubiquitin ligase TRIM63 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • ICC, IHC, FC
  • Background：  
  • Muscle specific RING finger protein (MuRF1) is a sarcomere-associated protein that is upregulated by conditions that provoke atrophy. Pharmacological or genetic inhibition of the IKKbeta/NF-kappaB/MuRF1 pathway reverses muscle atrophy, which presents MuRF as a target for clinical intervention. MuRF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy. MuRF1 directly associates with Titin kinase and influences microtubule-dependent signaling pathways in striated muscle and iris. MuRF1 upregulation is an indicator for skeletal muscle atrophy mechanisms that utilize ubiquitin-dependent proteolysis. MuRF1 transcript levels are high in situations where there is an overabundance of reactive oxygen species, such as cancer, AIDS and sepsis.



 
© Signalway Biotechnology All Rights Reserved.