Product Datasheet  
TFAP2A Antibody  
Catalog Number: 48390  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P05549
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:2,000

    ICC: 1:50-1:200

    FC: 1:50-1:100
  • other_names：  
  • Activating enhancer binding protein 2 alpha antibody
    Activating enhancer-binding protein 2-alpha antibody
    Activator protein 2 antibody
    AP 2 transcription factor antibody
    AP 2alpha antibody
    AP-2 antibody
    AP-2 transcription factor antibody
    AP2 antibody
    AP2 Transcription Factor antibody
    AP2-alpha antibody
    AP2A_HUMAN antibody
    AP2TF antibody
    BOFS antibody
    FLJ51761 antibody
    TFAP 2 antibody
    TFAP 2A antibody
    TFAP2 antibody
    TFAP2A antibody
    Transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha) antibody
    Transcription factor AP-2-alpha antibody
    Transcription factor AP2 alpha antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, FC
  • Background：  
  • AP-2 transcription factor family members include AP-2α, AP-2β and AP-2γ, which specifically bind to the DNA consensus sequence CCCCAGGC and initiate transcription of selected genes. AP-2, also known as ERF-1, plays a role in regulating estrogen receptor expression. AP-2β, a splice variant of AP-2α, inhibits AP-2 activity. Besides subscribing to the AP-2 complex, AP-2α, AP-2β and AP-2γ proteins compose the OB2-1 transcription factor complex. OB2-1 specifically upregulates expression of the proto-oncogene c-ErbB-2, which is overexpressed in 25-30% of breast cancers. AP-2α may play an important role in the development of ectodermal-derived tissues. Deleterious mutations involving the AP-2α gene are linked to microphthalmia, corneal clouding and other anterior eye chamber defects. The ubiquitously expressed AP-4 transcription factor specifically binds to the DNA consensus sequence 5'-CAGCTG-3'. AP-4 interacts with promoters for immunoglobulin-κ gene families and simian virus 40. AP-4 may enhance the transcription of the human Huntington's disease gene. AP-4 is a helix-loop-helix protein that contains two distinctive leucine repeat elements.



 
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