Product Datasheet  
XAF1 Antibody  
Catalog Number: 48349  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q6GPH4
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Amino acids 1-225 mapping at the N-terminus of XAF1 of human origin.
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:100-1:1,000


    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  • other_names：  
  • BIRC 4 binding protein antibody
    BIRC4 binding protein antibody
    BIRC4-binding protein antibody
    BIRC4BP antibody
    HSXIAPAF 1 antibody
    HSXIAPAF1 antibody
    XAF 1 antibody
    XAF1 antibody
    XAF1_HUMAN antibody
    XIAP associated factor 1 antibody
    XIAP-associated factor 1 antibody
    XIAPAF1 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF
  • Background：  
  • X-linked inhibitor of apoptosis protein (XIAP)-associated factor 1 (XAF1) is azinc finger protein that blocks the anti-apoptotic activity of XIAP. XIAP is amember of the family of intrinsic inhibitors of apoptosis proteins (IAPs), whichsuppress apoptosis through the inhibition of caspases. In the presence ofXAF1, XIAP protein redistributes from the cytosol to the nucleus. XAF1 transcripts(3.9-, 4.5-, 6.0- and 7.0-kb) are present at high levels in heart and ovary.Low expression of XAF1 mRNA is an indicator for certain cancers (WM164melanoma, WM35 melanoma, U937 pro-monocytic leukemia and HT1080fibrosarcoma), suggesting that low levels of XAF1 transcript may enhancecancer cell-survival through the relative increase in XIAP anti-apoptotic function.IFN-α and IFN-β activate the human XAF1 gene, which maps to chromosome17p13.1.



 
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