Product Datasheet
TNFR1 Antibody
Catalog Number: 48344
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.：
- Swiss-Prot#:P19438
- Form of Antibody：
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen：
- Amino acids 30-301 mapping within the extracellular domain of TNF-R1 of human origin.
- appl_detail：
- WB: 1:100-1:1,000
IHC: 1:50-1:500
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
- other_names：
- CD120a antibody FPF antibody MGC19588 antibody p55 antibody p55-R antibody p60 antibody TBP1 antibody TBPI antibody TNF R antibody TNF R55 antibody TNF-R1 antibody TNF-RI antibody TNFAR antibody TNFR-I antibody TNFR1 antibody TNFR55 antibody TNFR60 antibody TNFRI antibody TNFRSF1a antibody TNR1A_HUMAN antibody Tumor necrosis factor receptor 1 antibody Tumor necrosis factor receptor superfamily, member 1A antibody Tumor necrosis factor receptor type 1 antibody Tumor necrosis factor receptor type I antibody Tumor necrosis factor-binding protein 1 antibody
- Purification：
- Immunogen affinity purified
- Applications：
- WB, IP, IF, IHC(P)
- Background：
- Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors. These receptors, designated TNF-R1 and TNF-R2 are expressed on most cell types. The majority of TNF functions are primarily mediated through TNF-R1, while signaling through TNF-R2 occurs less extensively and is confined to cells of the immune system. Both of these proteins belong to the growing TNF and nerve growth factor (NGF) receptor superfamily, which includes FAS, CD30, CD27 and CD40. The members of this superfamily are type I membrane proteins that share sequence homology confined to the extracellular region. TNF-R1 shares a motif coined the death domain with FAS and three structurally unrelated signaling proteins, TRADD, FADD and RIP. This death domain is required for transduction of the apoptotic signal.
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