Product Datasheet  
TAL1 / SCL LS-C182473 Antibody  
Catalog Number: 48340  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P17542
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000


    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  • other_names：  
  • bHLHa17 antibody
    Class A basic helix-loop-helix protein 17 antibody
    OTTHUMP00000009563 antibody
    OTTHUMP00000009564 antibody
    SCL antibody
    STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR antibody
    Stem cell protein antibody
    T cell acute lymphocytic leukemia 1 antibody
    T cell acute lymphocytic leukemia 1 protein antibody
    T cell acute lymphocytic leukemia 1 protein antibody
    T cell leukemia/lymphoma 5 protein antibody
    T-cell acute lymphocytic leukemia protein 1 antibody
    T-cell leukemia/lymphoma protein 5 antibody
    Tal 1 antibody
    Tal 1 product antibody
    TAL 1 protein antibody
    TAL-1 antibody
    tal1 antibody
    TAL1_HUMAN antibody
    TCL 5 antibody
    TCL5 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF
  • Background：  
  • Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic coexpression of TAL1 and the catalytic subunit of casein kinase IIα, a serine/ threonine protein kinase known to modulate the activity of other βHLH transcription factors.



 
© Signalway Biotechnology All Rights Reserved.