Product Datasheet  
BRAP Monoclonal Antibody  
Catalog Number: 27218  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Uniprot: Q7Z569

    Gene ID: 8315

  • Form of Antibody：  
  • Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • store at -20˚C
  • Immunogen：  
  • Purified recombinant human BRAP protein fragments expressed in E.coli.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:1000

  • other_names：  
  • 3010002G07Rik; BRAP2; BRCA1 associated protein; EC 6.3.2.; Galectin 2 binding protein; IMP; Impedes mitogenic signal propagation; Renal carcinoma antigen NY REN 63; RING finger protein 52; RNF52; zgc:92894.
  • Purification：  
  • Affinity purified
  • Specificity：  
  • This antibody detects endogenous levels of BRAP and does not cross-react with related proteins.
  • Applications：  
  • WB
  • Background：  

  • Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.




 
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