Product Datasheet  
RPA70 Monoclonal Antibody  
Catalog Number: 27212  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Uniprot: P27694

    Gene ID: 6117

  • Form of Antibody：  
  • Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • store at -20˚C
  • Immunogen：  
  • Purified recombinant human RPA70 protein fragments expressed in E.coli.
  • reactivity：  
  • Hu Mk Ms Rt
  • appl_detail：  

  • Western blotting: 1:1000

    Immunocytochemistry: 1:100
  • other_names：  
  • Dmrpa1; Drosophila Replication Protein A; DRPA; HSSB; Human single stranded DNA binding protein; MST075; MSTP075; p70; REPA1; Replication factor A; Replication factor A protein 1; Replication protein A 70 kDa DNA-binding subunit;
  • Purification：  
  • Affinity purified
  • Specificity：  
  • This antibody detects endogenous levels of RPA70 and does not cross-react with related proteins.
  • Applications：  
  • WB ICC IP
  • Background：  

  •  Plays an essential role in several cellular processes in DNA metabolism including replication,recombination and DNA repair.Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.Functions as component of the alternative replication protein A complex (aRPA).aRPA binds single-stranded DNA and probably plays a role in DNA repair;it does not support chromosomal DNA replication and cell cycle progression through S-phase.In vitro,aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC),the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.




 
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