Product Datasheet  
PCNA Monoclonal Antibody  
Catalog Number: 27210  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Uniprot: P12004

    Gene ID: 5111

  • Form of Antibody：  
  • ascites
  • Storage：  
  • store at -20˚C
  • Immunogen：  
  • Purified recombinant human PCNA protein fragments expressed in E.coli.
  • reactivity：  
  • Hu Ms Mk Rt Hm
  • appl_detail：  

  • Western blotting: 1:1000

    Immunocytochemistry: 1:100
  • other_names：  
  • Cyclin; Cyclin; DNA polymerase delta auxiliary protein; DNA polymerase delta auxiliary protein; HGCN8729; MGC8367; MGC8367; Mutagen-sensitive 209 protein; OTTHUMP00000030189; OTTHUMP00000030190; PCNA; Pcna/cyclin; PCNA_HUMAN; PCNAR;
  • Purification：  
  • Specificity：  
  • This antibody detects endogenous levels of PCNA and does not cross-react with related proteins.
  • Applications：  
  • WB IP ICC IHC
  • Background：  

  •  Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase,but not apurinic-apyrimidinic (AP) endonuclease,APEX2 activities.Has to be loaded onto DNA in order to be able to stimulate APEX2.Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways.Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair:Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases,while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.




 
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