Product Datasheet  
DR5 Monoclonal Antibody  
Catalog Number: 27200  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Uniprot: O14763

    Gene ID: 8795

  • Form of Antibody：  
  • Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
  • Storage：  
  • store at -20˚C
  • Immunogen：  
  • Purified recombinant human TNFRSF10B protein fragments expressed in E.coli.
  • reactivity：  
  • Hu Ms
  • appl_detail：  

  • Western blotting: 1:500-1:2000

    Immunocytochemistry: 1:100
  • other_names：  
  • Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L;
  • Purification：  
  • Affinity purified
  • Specificity：  
  • This antibody detects endogenous levels of TNFRSF10B and does not cross-react with related proteins.
  • Applications：  
  • WB ICC
  • Background：  

  •  Receptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.Essential for ER stress-induced apoptosis.




 
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