Product Datasheet  
Smad2 Monoclonal Antibody  
Catalog Number: 27195  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Uniprot: Q15796

    Gene ID: 4087

  • Form of Antibody：  
  • ascites
  • Storage：  
  • store at -20˚C
  • Immunogen：  
  • Purified recombinant human SMAD2 protein fragments expressed in E.coli.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:500

    Immunocytochemistry: 1:100
  • other_names：  
  • hMAD 2; hMAD-2; hSMAD2; JV18 1; JV18; JV18; JV18-1; JV181; MAD; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers Against Decapentaplegic Homolog 2; Mothers Against Decapentaplegic Homolog 2;
  • Purification：  
  • Specificity：  
  • This antibody detects endogenous levels of SMAD2 and does not cross-react with related proteins.
  • Applications：  
  • WB ICC
  • Background：  

  •  Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and,on formation of the SMAD2/SMAD4 complex,activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.




 
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