Product Datasheet  
TORC1 Monoclonal Antibody  
Catalog Number: 27183  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Uniprot: Q6UUV9

    Gene ID: 23373

  • Form of Antibody：  
  • ascites
  • Storage：  
  • store at -20˚C
  • Immunogen：  
  • Purified recombinant human CRTC1 protein fragments expressed in E.coli.
  • reactivity：  
  • Hu Ms Mk Rt
  • appl_detail：  

  • Western blotting: 1:2000 

    Immunocytochemistry: 1:200
  • other_names：  
  • KIAA0616; CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; CRTC1_HUMAN; FLJ14027; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1;
  • Purification：  
  • Specificity：  
  • This antibody detects endogenous levels of CRTC1 and does not cross-react with related proteins.
  • Applications：  
  • WB ICC
  • Background：  

  •  Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.




 
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