Product Datasheet  
GRB2 Monoclonal Antibody  
Catalog Number: 27180  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Uniprot: P62993

    Gene ID: 2885

  • Form of Antibody：  
  • Ascites
  • Storage：  
  • store at -20˚C
  • Immunogen：  
  • Purified recombinant human GRB2 protein fragments expressed in E.coli.
  • reactivity：  
  • Hu Rt Ms Mk
  • appl_detail：  

  •  Western blotting: 1:500

  • other_names：  
  • Abundant SRC homology; Adapter protein GRB2; ASH; Ash protein; EGFRBP GRB2; Epidermal growth factor receptor binding protein; Epidermal growth factor receptor binding protein GRB2; GRB 2; GRB2 adapter protein; Grb2; GRB2_HUMAN; Grb3 3;
  • Purification：  
  • Specificity：  
  • This antibody detects endogenous levels of GRB2 and does not cross-react with related proteins.
  • Applications：  
  • WB
  • Background：  

  •  Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.




 
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