Product Datasheet  
Mouse anti-Human CD4, Purified mAb  
Catalog Number: 28010  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Form of Antibody：  
  • Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide
  • Storage：  
  • Store at 4°C.DO NOT FREEZE.
  • Immunogen：  
  • reactivity：  
  • Hu
  • appl_detail：  

  • Notice: This reagent has been pre-diluted for use at recommended volume per test in flow cytometry analysis. Typically add 10ul of this reagent to 100μl of experimental sample with 1 X 106 cells per test. Please refer to the detailed protocol when you perform a test.

  • other_names：  
  • Purification：  
  • Specificity：  
  • Applications：  
  • FC
  • Background：  

  •  CD4, also known as T4, is a 55 kD single chain transmembrane glycoprotein and belongs to immunoglobulin superfamily. CD4 is found on most thymocytes, a subset of T cells and at low level on monocytes/macrophages.

    CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction.
     
    1. Ledbetter, J et al. (1981) J Exp Med  153:310-323.
    2. Haynes , B et al. (1986) Leukocyte Typing II: Human T lymphocytes. New York: Sprimger-Verlag; 3-30.
    3. Clevers H et al. (1988). Ann Rev Immunol 6 : 629-662.
    4. Barclay, N et al. (1993). The Leucocyte Factsbook. Academic Press. San Diego.



 
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