Product Datasheet  
ORAI3 Monoclonal Antibody  
Catalog Number: 26028  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Mouse
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9BRQ5
    Gene ID:93129
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year.
  • Immunogen：  
  • A 19 amino acid peptide from near the carboxy terminus of human ORAI3.
  • reactivity：  
  • Hu Rt
  • appl_detail：  
  • other_names：  
  • ORAI3 (2H2G9), Transmembrane protein 142C, TMEM142C, Calcium release-activated calcium channel protein 3
  • Purification：  
  • Immunoaffinity chromotography purified IgG
  • Specificity：  
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.



 
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