Product Datasheet  
Acetyl CoA Carboxylase 1(ACC1) Antibody  
Catalog Number: HW227  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q13085
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:1,000
    IHC: 1:50-1:200


  • other_names：  
  • ACAC antibody
    ACACA antibody
    ACACA_HUMAN antibody
    ACACB antibody
    ACC alpha antibody
    ACC antibody
    ACC beta antibody
    ACC-alpha antibody
    ACC1 antibody
    ACC2 antibody
    ACCA antibody
    ACCB antibody
    Acetyl CoA carboxylase 1 antibody
    Acetyl CoA carboxylase 2 antibody
    Acetyl CoA carboxylase alpha antibody
    Acetyl CoA carboxylase beta antibody
    Acetyl Coenzyme A carboxylase alpha antibody
    Acetyl Coenzyme A carboxylase beta antibody
    Biotin carboxylase antibody
    COA1 antibody
    COA2 antibody
    HACC275 antibody
    OTTHUMP00000164069 antibody
    OTTHUMP00000164070 antibody
    OTTHUMP00000164076 antibody
    OTTHUMP00000240532 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IHC
  • Background：  
  • Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzymes short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus.



 
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