Product Datasheet
Histone H4K20me2 Polyclonal Antibody
Catalog Number: HW032
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Gene ID: 8290 Swiss Prot: Q16695
- Form of Antibody:
- Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
- Storage:
- Store at -20�?or -80�? Avoid freeze / thaw cycles.
- Immunogen:
- A synthetic methylated peptide corresponding to residues surrounding K20 of human histone H4
- appl_detail:
WB 1:500 - 1:2000
IF 1:50 - 1:200
IP 1:50 - 1:200
CHIP 1:50 - 1:200
- other_names:
- H4; H4/n; H4F2; H4FN; FO108; HIST2H4
- Purification:
- Antibodies were produced by immunizing rabbits and were purified by antigen affinity-chromatography.
- Applications:
- WB IF IP ChIP
- Background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
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