NUDT15 Polyclonal Antibody

Catalog Number:

28443

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9NV35
NCBI Gene ID:55270

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human NUDT15 (NP_060753.1).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:100 - 1:200

Datasheet PDF