ALDH18A1 Polyclonal Antibody

Catalog Number:

27661

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P54886
NCBI Gene ID:5832

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human ALDH18A1 (NP_002851.2).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF