C2 Polyclonal Antibody

Catalog Number:

27320

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P06681
NCBI Gene ID:717

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human C2 (NP_000054.2).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF