HLA-F Polyclonal Antibody

Catalog Number:

27409

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P30511
NCBI Gene ID:3134

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human HLA-F (NP_001091949.1).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF