BICD1 Antibody

Catalog Number:

24710

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q96G01
Gene ID:636

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 15 amino acid peptide from near the carboxy terminus of human BICD1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of BICD1 are known to exist; this antibody will only recognize the larger isoform.

Applications:

ELISA WB ICC

Background:

BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.

References:

appl_detail:

Datasheet PDF