Wnt10a Antibody

Catalog Number:

24699

Amount:

100μg

Price:

$319

Swiss-Prot No:

Q9GZT5

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 14 amino acid peptide from near the carboxy terminus of human Wnt10a.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Despite the high homology of Wnt10a to Wnt10b, this Wnt10a antibody will not cross-react with Wnt10b.

Applications:

ELISA WB IHC

Background:

Wnt10a is a member of the Wnt family, a gene family that encodes secreted signaling proteins that play crucial roles in normal development such as regulation of cell fate and patterning during embryogenesis as well as neoplastic transformation. Elevated levels of Wnt10a have been detected in several human tumors and cancer cell lines including colorectal cancer and chronic lymphocytic leukemia and it has been suggested that uncontrolled Wnt signaling may contribute to the defect in apoptosis that characterizes these malignancies. Recently, a mutation in Wnt10a was found to be associated with odonto-onycho-dermal dysplasia, an autosomal recessive ectodermal dysplasia.

References:

appl_detail:

Datasheet PDF