Ikaros Rabbit mAb

Catalog Number:

78485

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q13422

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Ikaros

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IF,ChIP

Background:

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

References:

appl_detail:

WB 1:500 - 1:2000
IF 1:50 - 1:200
ChIP 1:20 - 1:200

Datasheet PDF