Bcl10 Rabbit mAb

Catalog Number:

77956

Amount:

100μg

Price:

$318

Swiss-Prot No:

O95999

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Bcl10

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF