PEN2/PSENEN Rabbit mAb

Catalog Number:

77862

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q9NZ42

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human PEN2/PSENEN

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IF

Background:

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

References:

appl_detail:

WB 1:500 - 1:2000
IF 1:50 - 1:200

Datasheet PDF