GTPBP4 Rabbit mAb

Catalog Number:

77802

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q9BZE4

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human GTPBP4

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200

Datasheet PDF