ARRB1 Rabbit mAb

Catalog Number:

77793

Amount:

100μg

Price:

$318

Swiss-Prot No:

P49407

Form of Antibody:

Storage/Stability:

Immunogen:

Recombinant protein of human ARRB1

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF