CD35/CR1 Rabbit mAb

Catalog Number:

77714

Amount:

100μg

Price:

$318

Swiss-Prot No:

P17927

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human CD35/CR1

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

IHC,IF

Background:

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

References:

appl_detail:

IHC 1:50 - 1:200
IF 1:50 - 1:200

Datasheet PDF