APEX1/APE1 Rabbit mAb

Catalog Number:

77713

Amount:

100μg

Price:

$318

Swiss-Prot No:

P27695

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human APEX1/APEX1/APE1

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200

Datasheet PDF