Tropomyosin 1 Rabbit mAb

Catalog Number:

77686

Amount:

100μg

Price:

$318

Swiss-Prot No:

P09493

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Tropomyosin 1

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC,IF,IP

Background:

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:200

Datasheet PDF