GABA transaminase (ABAT) Rabbit mAb

Catalog Number:

77670

Amount:

100μg

Price:

$318

Swiss-Prot No:

P80404

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human GABA transaminase (GABA transaminase (ABAT))

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200

Datasheet PDF