Exportin 2 (XPO2) Rabbit mAb

Catalog Number:

77668

Amount:

100μg

Price:

$318

Swiss-Prot No:

P55060

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Exportin 2 (XPO2)

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF