Phospho-RB-S780 Rabbit mAb

Catalog Number:

77589

Amount:

100μg

Price:

$318

Swiss-Prot No:

P06400

Form of Antibody:

Storage/Stability:

Immunogen:

A phospho synthetic peptide corresponding to residues surrounding S780 of human RB.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200

Datasheet PDF