MBD2 Rabbit mAb

Catalog Number:

77491

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q9UBB5

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human MBD2

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF