TAB3 Rabbit mAb

Catalog Number:

77375

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q8N5C8

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human TAB3

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF