PD-L1/CD274 Rabbit mAb

Catalog Number:

77056

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q9NZQ7

Form of Antibody:

Storage/Stability:

Immunogen:

Recombinant protein of human PD‐L1 extracellular domain.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

IHC

Background:

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

IHC 1:50 - 1:200

Datasheet PDF