1-832-206-4069
order@swbio.com
catalog number: |
42901 |
| other_names: | dap12; karap; plosl |
amount: |
100μg |
| calculated_mw: | |
| host_species: | rabbit |
price: |
$319 |
swiss-prot no: |
swiss-prot#: o43914 |
form of antibody: |
rabbit igg in ph7.4 pbs, 0.05% nan3, 40% glycerol. |
storage/stability: |
|
immunogen: |
full length fusion protein of human tyrobp |
purification: |
antigen affinity purification. |
specificity/sensitivity: |
the antibody detects endogenous levels of total tyrobp protein. |
applications: |
ihc |
background: |
this gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (itam) in its cytoplasmic domain. the encoded protein may associate with the killer-cell inhibitory receptor (kir) family of membrane glycoproteins and may act as an activating signal transduction element. this protein may bind zeta-chain (tcr) associated protein kinase 70kda (zap-70) and spleen tyrosine kinase (syk) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (plosl), also known as nasu-hakola disease. its putative receptor, triggering receptor expressed on myeloid cells 2 (trem2), also causes plosl. multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.? |
references: |
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appl_detail: |
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